Low-Dose Maintenance Chemo for High-Risk Rhabdomyosarcoma

For the vast majority of patients with rhabdomyosarcoma, a rare soft-tissue sarcoma occurring more commonly in children, standard therapy comprising of surgery, radiation, and high-dose chemotherapy leads to long-term survival and potential cure. However, for high-risk patients or those who progress on first-line therapy, outcomes are poor. With a cure rate of only 20% to […]

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Pembrolizumab and Chemo Combo New Option for Squamous NSCLC

In recent years immunotherapy with PD-1 inhibitors has become the standard of care for first-line treatment of patients with nonsquamous non-small cell lung cancer (nonsq NSCLC) in the absence of targetable driver mutations. For patients with PD-L1 expression >50%, pembrolizumab monotherapy is an approved treatment option for both nonsq and squamous (sq) NSCLC. Based on […]

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Adjuvant mFOLFIRINOX, New Standard of Care for Resectable Pancreatic Cancer

The most common treatment approach for patients with resectable pancreatic cancer is surgery, followed by six cycles of adjuvant chemotherapy with gemcitabine or, more recently, with gemcitabine/capecitabine in combination. Unfortunately, the majority of patients relapse within two years, highlighting a need for improved treatment options for early stage pancreatic cancer. At the 2018 American Society […]

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Clinically Meaningful Progression-Free Survival Benefit With Ribociclib and Fulvestrant in Advanced HR-Positive Breast Cancer

In recent years, cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors have become standard of care in combination with endocrine therapy for patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC). Ribociclib is a CDK 4/6 inhibitor that has recently been approved, in combination with an aromatase inhibitor, for first-line […]

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Practice-Changing Results From TAILORx Trial in Early Breast Cancer

For women with node-negative, hormonal receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative, early breast cancer, the 21-gene recurrence score (RS) assay can be used to predict risk of recurrence and to tailor treatment. Patients with low RS (0-10) have low risk of recurrence when treated with endocrine therapy alone, while patients with high RS […]

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Upfront Cytoreductive Nephrectomy Not Needed Before Targeted Therapy in mRCC

For patients with metastatic renal cell carcinoma (mRCC), initial treatment typically includes cytoreductive nephrectomy followed by angiogenesis inhibitor therapy. While retrospective analyses have historically shown that patients who receive a nephrectomy have prolonged survival compared to those who do not, no study has directly compared nephrectomy and targeted therapy in patients newly diagnosed with mRCC. […]

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Optimizing Treatment for Patients With Relapsed Multiple Myeloma

Optimizing Treatment for Patients With Relapsed Multiple Myeloma At the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, cutting edge research and paradigm-changing data were presented across different tumor types, including multiple myeloma. Some of the new findings from the phase III clinical trials in relapsed refractory multiple myeloma (RRMM) will likely impact current […]

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Important New FDA Approvals in May for Patients With Cancer

Combo Dabrafenib/Trametinib for BRAF-Mutated Thyroid Cancer. The United States Food and Drug Administration (FDA) expanded the indication of the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib (Tafinlar® and Mekinist®, Novartis) in combination to include use in patients with BRAFV600E-mutated anaplastic thyroid cancer. This approval was based on results from a multicohort, nonrandomized, phase II […]

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