Diffuse Large B-Cell Lymphoma (DLBCL)

Diffuse large B-cell lymphoma (DLBCL) is a type of non-Hodgkin lymphoma (NHL), a cancer that develops in the lymphatic system, most commonly in lymph nodes. Diffuse large B-cell lymphoma is the most common high-grade (aggressive) type of NHL. B-cell lymphomas, in general, are far more common than T-cell lymphomas.  Diffuse large B-cell lymphoma affects more men than women, and though it can occur at any age, is more commonly diagnosed in people over the age of 60 years.

disease. The clinical presentation of DLBCLs are diverse and vary depending on site of involvement. However, diffuse large B-cell lymphoma may cause one or more of the following:

  • Abdominal pain
  • Coughing or shallow breath
  • Excessive night sweats
  • Fatigue
  • Fever
  • Itching
  • Swollen lymph nodes
  • Unexplained weight loss

The exact underlying cause or causes of DLBCL are unknown. Potential risk factors are not always evident. Some factors may include exposure to chemicals or radiation, genetic predisposition, and having certain autoimmune diseases. Diffuse large B-cell lymphoma may be hard to diagnose due to a variety of symptoms that vary based on the specific organs or tissues affected by the lymphoma. Treatment plans typically depend on the stage and presenting symptoms.

Treatment options for DLBCL may include one or more of the following:

  • Chemotherapy
  • Chemoimmunotherapy
  • Radiation therapy
  • Stem cell transplant