Leptomeningeal Involvement of Cancer

Leptomeningeal involvement of cancer is when certain types of cancer spread to a patient’s meninges, the layers of tissue that cover and protect the brain and spinal cord, cerebrospinal fluid (CSF), or both. When cancer cells are found in either the CSF or the meninges, it is referred to as leptomeningeal metastases (LM).

Symptoms of LM include:

  • Seizures
  • Difficulty thinking
  • Double vision
  • Difficulty speaking or swallowing
  • Headaches
  • Weakness or lack of coordination in legs or arm
  • Loss of bladder or bowel control

Treatment for LM can include:

  • Radiation
  • Chemotherapy (delivered straight into the CSF)