Decisions in Advanced Renal Cell Cancer - prIME Oncology
prIME Decision Points
prIME Decision Points

Decisions in Advanced Renal Cell Cancer

Identifying the Right Treatment Option for Each Patient

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The information in this activity is intended for healthcare professionals based outside of the United States. This activity may contain information on products outside the approved indications where you practice.

Hear from the experts about the best strategies to optimize patient outcomes in advanced renal cell cancer (RCC), which include optimizing continuum of care and fine-tuning systemic therapy in advanced RCC. A clinical scenario with patient history and options for next steps in treatment provides the foundation for commentary and insight into decision making in the care of your patients with advanced RCC.

Interactive Presentation

Interactive Presentation



Release Date

Release Date

Dec 10, 2018

Expiration Date

Dec 10, 2019

  • Bernard Escudier, MDGustave Roussy
    Villejuif, France
  • Manuela Schmidinger, MDMedical University of Vienna
    Vienna, Austria
  • Introduction
  • Decision point 1: First-line systemic therapy for metastatic RCC—getting the most out of the available options
  • Decision point 2: Dealers’ choice or evidence-based recommendations—second-line options for disease control
  • Decision point 3: Keep on running—later-line options for disease control
  • prIME Points™

This educational activity is designed for urologists, medical oncologists, urology and oncology specialist nurses, and other healthcare professionals involved in the management of patients with RCC.

After successful completion of this educational activity, participants should be able to:

  • Describe recent findings from clinical trials investigating targeted therapies and immune checkpoint inhibitors either as single agents or in combination for locally advanced and metastatic RCC
  • Identify the subgroups of patients with metastatic RCC best treated in the first-line setting by tyrosine kinase inhibitors or immunotherapy agents or a combination of the two
  • Define a clinical algorithm to aid the selection and sequencing of available options for the treatment of metastatic RCC

This educational activity is supported by a grant from Pfizer Oncology.

Independent Medical Education (IME)

This IME activity is organized by prIME Oncology. This activity provides content that is evidence-based, balanced, and free of commercial bias, with a primary objective to improve competence and performance of learners in order to improve patient care.


This activity is provided by prIME Oncology.

Disclosure Information

Disclosure of Relevant Financial Relationships

prIME Oncology assesses relevant financial relationships with its instructors, planners, managers, and other individuals who are in a position to control the content of IME activities. Any potential conflicts of interest that are identified are thoroughly vetted by prIME Oncology for fairness, balance, and scientific objectivity of data, as well as patient care recommendations. prIME Oncology is committed to providing its learners with high-quality IME activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial entity.

The faculty reported the following financial relationships or relationships to products or devices they or their spouses/life partners have with commercial interest related to the content of this activity:

Dr Escudier has disclosed that he has a board membership with Bristol-Myers Squibb, Ipsen, Pfizer, and Roche. He has received consulting fees from Bristol-Myers Squibb, Ipsen, Novartis, Pfizer, and Roche. He has agreed to disclose any unlabeled/unapproved uses of drugs or products referenced in his presentation.

Dr Schmidinger has disclosed that she has a board membership with ESMO. She also received consulting fees from Astellas, Bristol-Myers Squibb, Eisai, Eusa, Exelixis, Ipsen, Novartis, Pfizer, and Roche. She has agreed to disclose any unlabeled/unapproved uses of drugs or products referenced in her presentation.

The employees of prIME Oncology have disclosed:

  • Robert Coleman, MD, FRCP, FRCPE (medical director content reviewer/planner) – chair of Inbiomotion Scientific and Clinical Advisory Board; consulting fees for advising on clinical trial protocol development from Amgen, Astellas, and Boehringer Ingelheim; intellectual property rights as co-inventor and patent holder of biomarker under development by Inbiomotion; independent medical education lectures at symposia supported by Amgen, Eisai, and Genomic Health; and travel expenses from Amgen for presentation of clinical trial data at ASCO 2018 conference
  • Sanneke Koekkoek, PhD (scientific content reviewer/planner) – no relevant financial relationships
  • Jessica Mastrodomenico, MPH (editorial content reviewer) – no relevant financial relationships


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Disclosure Regarding Unlabeled Use

This activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration or European Medicines Agency. Please refer to the official prescribing information for each product discussed for discussions of approved indications, contraindications, and warnings.