Key Advances and Updates in HR-Positive Breast Cancer - prIME Oncology
Clinical Spotlight
Clinical Spotlight

Key Advances and Updates in HR-Positive Breast Cancer

News From the 2018 European Oncology Congress in Munich

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The information in this activity is intended for healthcare professionals based outside of the United States. You will be asked to provide your credentials before participating in the activity. This activity may contain information on products outside the approved indications where you practice.

This breast cancer thought-leader discussion, with associated slide deck and eNewsflash, provides participants with valuable updates and expert perspectives on exciting new data in hormone receptor (HR)-positive breast cancer released at the 2018 European Oncology Congress in Munich.

Interactive Presentation

Interactive Presentation

Downloadable Slides

Downloadable Slides





Release Date

Release Date

Oct 25, 2018

Expiration Date

Oct 25, 2019

Featured Experts

  • Robert Coleman, MD, FRCP, FRCPE, Medical Director, prIME Oncology, University of Sheffield
    Weston Park Hospital, Sheffield, United Kingdom
  • Richard de Boer, MBBS, FRACP, Royal Melbourne Hospital, Melbourne, Australia
  • Hope S. Rugo, MD, FASCO, University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States

Featured Topics

Abstract #LBA2: Overall survival (OS) with palbociclib plus fulvestrant in women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) advanced breast cancer (ABC): Analyses from PALOMA-3

Abstract #LBA3_PR: Alpelisib (ALP) + fulvestrant (FUL) for advanced breast cancer (ABC): Results of the Phase 3 SOLAR-1 trial

Abstract #232P: A multicentre, international neoadjuvant, double-blind, randomized phase III trial comparing fulvestrant to a combination of fulvestrant and palbociclib (CDK 4/6 inhibitor) in patients with operable luminal breast cancer responding to fulvestrant (SAFIA study

Abstract #290O: Patient-reported outcomes (PROs) in advanced breast cancer (ABC) treated with ribociclib + fulvestrant: Results from MONALEESA-3

Abstract #291O: Ribociclib (RIB) + tamoxifen (TAM) or a non-steroidal aromatase inhibitor (NSAI) in premenopausal patients (pts) with hormone receptor-positive (HR+), HER2-negative (HER2–) advanced breast cancer (ABC): MONALEESA-7 patient-reported outcomes (PROs)

Abstract #293PD_PR: Ribociclib (RIBO) + letrozole (LET) in male patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor-2–negative (HER2–) advanced breast cancer (ABC) and no prior endocrine therapy (ET) for ABC: Preliminary subgroup results from the phase 3b CompLEEment-1 trial

Abstract #339P: Management of abemaciclib associated adverse events in patients with hormone receptor positive (HR+), HER2- advanced breast cancer: analysis of the MONARCH trials


  • Robert Coleman, MD, FRCP, FRCPEMedical Director, prIME Oncology
    University of Sheffield
    Weston Park Hospital
    Sheffield, United Kingdom


  • Richard de Boer, MBBS, FRACPRoyal Melbourne Hospital
    Melbourne, Australia
  • Hope S. Rugo, MD, FASCOUniversity of California, San Francisco
    Helen Diller Family Comprehensive Cancer Center
    San Francisco, California, United States

This educational activity is specifically designed for oncologists and other healthcare professionals involved in the management of patients with HR-positive breast cancer.

After successful completion of this educational activity, participants should be able to:

  • Evaluate emerging clinical trial data investigating the safety and efficacy of combination approaches for HR-positive, HER2-negative breast cancer
  • Select appropriate treatment approaches for HR-positive, HER2-negative breast cancer and identify the optimal sequence of treatment options

This educational activity is supported by a grant from Novartis Oncology.

Independent Medical Education (IME)

This IME activity is organized by prIME Oncology. This activity provides content that is evidence-based, balanced, and free of commercial bias, with a primary objective to improve competence and performance of learners in order to improve patient care.


This activity is provided by prIME Oncology.

Disclosure Information

Disclosure of Relevant Financial Relationships

prIME Oncology assesses relevant financial relationships with its instructors, planners, managers, and other individuals who are in a position to control the content of IME activities. Any potential conflicts of interest that are identified are thoroughly vetted by prIME Oncology for fairness, balance, and scientific objectivity of data, as well as patient care recommendations. prIME Oncology is committed to providing its learners with high-quality IME activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial entity.

The faculty reported the following financial relationships or relationships to products or devices they or their spouses/life partners have with commercial interest related to the content of this activity:

The employees of prIME Oncology have disclosed:

  • Robert Coleman, MD, FRCP, FRCPE (medical director content reviewer/planner) – consulting fees for advising on clinical trial protocol development from Amgen, Astellas, and Boehringer Ingelheim; intellectual property rights as co-inventor and patent holder of biomarker under development by Inbiomotion; independent medical education lectures at symposia supported by Amgen, Eisai, and Genomic Health; and travel expenses from Amgen for presentation of clinical trial data at ASCO 2018 conference
  • Amy Furedy, RN, OCN (scientific content reviewer/planner) – no relevant financial relationships
  • Heather Tomlinson, ELS (editorial content reviewer) – no relevant financial relationships