Key Ovarian Data From the 2018 Oncology Annual Meeting - prIME Oncology
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prIME Clinical Update

Key Ovarian Data From the 2018 Oncology Annual Meeting

Critical Analysis and Practical Application From Chicago

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Get the latest information from the 2018 Annual Oncology Meeting in Chicago. Experts in ovarian cancer discuss and analyze the new data and its potential impact on clinical practice.

Interactive Presentation

Interactive Presentation

CME

CME

0.75 AMA PRA Category 1 Credits™

Release Date

Release Date

Jun 8, 2018

Expiration Date

Jun 8, 2019

Ovarian Cancer – PARP Inhibitors

Featured Experts

  • Bradley J. Monk, MD, FACS, FACOG, Arizona Oncology (US Oncology Network)
    University of Arizona College of Medicine-Phoenix, Creighton University School of Medicine at St Joseph's Hospital, Phoenix, Arizona, United States
  • Kathleen Moore, MD, Stephenson Cancer Center, University of Oklahoma, Oklahoma City, Oklahoma, United States

Featured Topics

Abstract #5514: QUADRA: A phase 2, open-label, single-arm study to evaluate niraparib in patients (pts) with relapsed ovarian cancer (ROC) who have received ≥3 prior chemotherapy regimens

Abstract #106: TOPACIO/Keynote-162 (NCT02657889): A phase 1/2 study of niraparib + pembrolizumab in patients (pts) with advanced triple-negative breast cancer or recurrent ovarian cancer (ROC)—Results from ROC cohort

Abstract #5519: A phase 2 biomarker trial of combination cediranib and olaparib in relapsed platinum (plat) sensitive and plat resistant ovarian cancer (ovca)

 

Ovarian cancer – Novel therapies

Featured Experts

  • Bradley J. Monk, MD, FACS, FACOG, Arizona Oncology (US Oncology Network)
    University of Arizona College of Medicine-Phoenix, Creighton University School of Medicine at St Joseph's Hospital, Phoenix, Arizona, United States
  • David O’Malley, MD, The Ohio State University, James Comprehensive Cancer Center, Columbus, Ohio, United States

Featured Topics

Abstract #5549: Mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients (pts) with platinum-resistant ovarian cancer: Maturing safety and activity profile from the FORWARD II phase 1b study

Abstract #5511: Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: Interim results from the phase 2 KEYNOTE-100 study

Abstract #5509: Dendritic cell vaccine (DCVAC) with chemotherapy (ct) in patients (pts) with epithelial ovarian carcinoma (EOC) after primary debulking surgery (PDS): Interim analysis of a phase 2, open-label, randomized, multicenter trial

Abstract #5517: Final overall survival (OS) analysis of an international randomized trial evaluating bevacizumab (BEV) in the primary treatment of advanced ovarian cancer: A NRG oncology/Gynecologic Oncology Group (GOG) study

Abstract #5518: AGO-OVAR 16: A phase III study to evaluate the efficacy and safety of pazopanib (PZ) monotherapy versus placebo in women who have not progressed after first line chemotherapy for epithelial ovarian, fallopian tube, or primary peritoneal cancer—Overall survival (OS) results

Abstract #5515: Apatinib, a novel VEGFR inhibitor, combined with oral etoposide in patients with platinum-resistant or platinum-refractory ovarian cancer: A single-arm, open-label, phase 2 study

Abstract #TPS5614: INNOVATE-3: Phase 3 randomized, international study of tumor treating fields (200 kHz) concomitant with weekly paclitaxel for the treatment of platinum-resistant ovarian cancer

Abstract #5514: QUADRA: A phase 2, open-label, single-arm study to evaluate niraparib in patients (pts) with relapsed ovarian cancer (ROC) who have received ≥3 prior chemotherapy regimens

  • Bradley J. Monk, MD, FACS, FACOGArizona Oncology (US Oncology Network)
    University of Arizona College of Medicine-Phoenix
    Creighton University School of Medicine at St Joseph's Hospital
    Phoenix, Arizona, United States
  • Kathleen Moore, MDStephenson Cancer Center
    University of Oklahoma
    Oklahoma City, Oklahoma, United States
  • David O’Malley, MDThe Ohio State University
    James Comprehensive Cancer Center
    Columbus, Ohio, United States

This educational activity is specifically designed for clinicians who are cancer specialists.

After successful completion of this educational activity, participants should be able to:

  • Discuss key data from the conference
  • Apply key data from the conference to clinical practice, as appropriate

This educational activity is supported by grants from Celgene Corporation; ImmunoGen, Inc.; Merck and Co, Inc.; and TESARO, Inc.

Continuing Education

prIME Oncology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Key Ovarian Data From the 2018 Oncology Annual Meeting - prIME Oncology

prIME Oncology designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  • Ovarian PARP Inhibitors: 0.25
  • Ovarian Novel Therapies: 0.5

Provider

This activity is provided by prIME Oncology.

Disclosure Information

Method of Participation

There are no fees for participating in and receiving CME credit for this activity. In order to receive credit, participants must successfully complete the online posttest and activity evaluation. Your participation in this CME activity will be recorded in prIME Oncology’s database. However, upon request, your CME credit certificate will be emailed to you. Technical requirements may be found under the Terms of Use.

Links to the post-test are available on the video player pages.

In order to receive credit, participants must successfully complete the online posttest with 75% or higher.

Disclosure of Relevant Financial Relationships

prIME Oncology assesses relevant financial relationships with its instructors, planners, managers, and other individuals who are in a position to control the content of CME activities. Any potential conflicts of interest that are identified are thoroughly vetted by prIME Oncology for fairness, balance, and scientific objectivity of data, as well as patient care recommendations. prIME Oncology is committed to providing its learners with high-quality CME activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial entity.

The faculty reported the following financial relationships or relationships to products or devices they or their spouses/life partners have with commercial interest related to the content of this activity:

Dr Monk has disclosed that he has received honoraria or consultation fees from Advaxis, Aravive, Geistlich, Genmab, Immunogen Inc, Mateon Therapeutics Inc (formerly Oxigene), Merck, Myriad, Perthera, Pfizer, Takeda, and VBL. He has also disclosed honoraria for participation in promotional  speaker’s bureaus and consulting for AstraZeneca, Clovis, Janssen/Johnson & Johnson, Roche/Genentech, and TESARO, Inc. He has agreed to disclose any unlabeled/unapproved uses of drugs or products referenced in his presentation.

Dr Moore has disclosed that she has been a member on advisory committees or review panels for AstraZeneca, Genentech/Roche, ImmunoGen, and VBL Therapeutics. She has also disclosed ownership interest in Clovis, Janssen, and TESARO, Inc. She has agreed to disclose any unlabeled/unapproved uses of drugs or products referenced in her presentation.

Dr O’Malley has disclosed that he has participated in consulting and/or advisory boards for AbbVie, AstraZeneca, Clovis, Janssen, Myriad, and TESARO, Inc. He has agreed to disclose any unlabeled/unapproved uses of drugs or products referenced in his presentation.

The employees of prIME Oncology have disclosed:

  • Angela Zimmermann, PhD (scientific content reviewer/planner) – no relevant financial relationships
  • Amy Furedy, RN, OCN (scientific content reviewer/planner) – no relevant financial relationships
  • Jessica Mastrodomenico, MPH (editorial content reviewer) – no relevant financial relationships

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Disclosure Regarding Unlabeled Use

This activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration or European Medicines Agency. Please refer to the official prescribing information for each product discussed for discussions of approved indications, contraindications, and warnings.