Practice-Changing Developments in ER-Positive Breast Cancer - prIME Oncology
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Clinical Spotlight

Practice-Changing Developments in ER-Positive Breast Cancer

From the 2017 European Oncology Congress in Madrid

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The information in this activity is intended for healthcare professionals based outside of the United States. This activity may contain information on products outside the approved indications where you practice.

Update your treatment options via this breast cancer thought leader discussion, with associated slide deck and eNewsflash, featuring valuable updates and expert perspectives on exciting new developments in the management of breast cancer released at the 2017 European Oncology Congress in Madrid.

Interactive Presentation

Interactive Presentation

Downloadable Slides

Downloadable Slides



Release Date

Release Date

Sep 15, 2017

Expiration Date

Sep 15, 2018

Abstract #236O_PR: MONARCH 3: Abemaciclib as initial therapy for patients with HR+/HER2- advanced breast cancer

Abstract #LBA9: Letrozole and palbociclib versus 3rd generation chemotherapy as neoadjuvant treatment of luminal breast cancer: Results of the UNICANCER-NeoPAL study

Abstract #LBA10_PR Primary results of LORELEI: A phase II randomized, double-blind study of neoadjuvant letrozole (LET) plus taselisib versus LET plus placebo (PLA) in postmenopausal patients (pts) with ER+/HER2-negative early breast cancer (EBC)

Abstract #148O: Phase III evaluating the addition of fulvestrant (F) to anastrozole (A) as adjuvant therapy in postmenopausal women with hormone receptor positive HER2 negative (HR+/HER2-) early breast cancer (EBC): Results from the GEICAM/2006-10 study

Abstract #245PD: Duration of response and tumor shrinkage with first-line ribociclib + letrozole in postmenopausal women with HR+, HER2– ABC

Abstract #248P: Impact of prior treatment on palbociclib plus letrozole (P+L) efficacy and safety in patients (pts) with estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2–) first-line advanced breast cancer (ABC): A PALOMA-2 subgroup analysis

Abstract #249P: Analysis of overall survival by tumor response in MONARCH 1, a phase 2 study of abemaciclib, a CDK4 and CDK6 inhibitor, in women with HR+/HER2- metastatic breast cancer (MBC) after chemotherapy for advanced disease

Abstract #254P: Matching-adjusted indirect treatment comparison of ribociclib and palbociclib as first-line treatments for HR+, HER2– ABC

Abstract #256P: Efficacy of palbociclib plus fulvestrant in advanced hormone receptor-positive (HR+) metastatic breast cancer (MBC) pretreated with everolimus: Real-life data from the French Temporary Authorization for Use (TAU) at the Institut de Cancérologie de l’Ouest

Featured Experts

  • Robert Coleman, MD, FRCP, FRCPEMedical Director, prIME Oncology
    University of Sheffield
    Weston Park Hospital
    Sheffield, United Kingdom
  • Nadia Harbeck, MD, PhDUniversity of Munich
    Munich, Germany
  • Sunil Verma, MD, MSEd, FRCPCTom Baker Cancer Centre
    Calgary, Alberta, Canada

After successful completion of this educational activity, participants should be able to:

  • Examine the role of cyclins and cyclin-dependent kinases in the biology of ER-positive disease and the mechanism of action of the range of CDK4/6 inhibitors in development
  • Summarize the clinical application of novel combinations of targeted and endocrine therapy for the first- and second-line treatment of ER-positive, HER2-negative advanced breast cancer
  • Select appropriate treatment combinations for ER-positive, HER2-negative breast cancer, and identify the optimal sequence of treatment options

This educational activity is supported by a grant from Novartis Oncology.

Enduring Materials From a Certified Activity

This enduring material, derived from a certified live event, contains content that is evidence-based, balanced, and free of commercial bias. While the content was planned and implemented by prIME Oncology for a certified live event, this activity does not offer continuing education credit.


This activity is provided by prIME Oncology.

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Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Disclosure Regarding Unlabeled Use

This activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration or European Medicines Agency. Please refer to the official prescribing information for each product discussed for discussions of approved indications, contraindications, and warnings.