conference news

Significant Activity for Tucatinib in Progressive Metastatic HER2-Positive Breast Cancer

At the 2019 San Antonio Breast Cancer Symposium (SABCS), Rashmi Murthy, MD (University of Texas MD Anderson Cancer Center, Houston, United States), presented results from the randomized phase III HER2CLIMB trial, which evaluated the addition of the HER2-targeting tyrosine kinase inhibitor (TKI) tucatinib to trastuzumab and capecitabine in 612 patients with progressive metastatic HER2-positive breast […]

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Conference coverage

Capecitabine Improves Survival in Early-Stage Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is difficult to treat due to the lack of targetable receptors, and patients often have poor outcomes due to the lack of effective treatment options. At the 2019 San Antonio Breast Cancer Symposium (SABCS), Marion van Mackelenbergh, MD (University of Kiel, Germany), presented results from a subgroup of patients with early-stage […]

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Blinatumomab More Effective than Chemotherapy in Relapsed ALL

Children as well as adolescent and young adult (AYA) patients with acute lymphoblastic leukemia (ALL) who relapse following frontline therapy typically receive intensive chemotherapy followed by hematopoietic stem cell transplant (HSCT). Unfortunately, this treatment option is not always effective, and these patients tend to have poor outcomes. At the 2019 American Society of Hematology (ASH) […]

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Carfilzomib Dara Combo Prolongs PFS in Relapsed/Refractory Multiple Myeloma

At the 2019 American Society for Hematology (ASH) Annual Meeting, Saad Usmani, MD, MBBS (Atrium Health, Charlotte, North Carolina, United States), presented results from the randomized phase III CANDOR trial, evaluating the combination of carfilzomib, dexamethasone, and daratumumab (KdD) for treatment of patients with relapsed/refractory multiple myeloma (Abstract LBA6). Patients (N = 466) who had […]

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Predicting Six-Month Mortality Among Patients With Cancer

When physicians have conversations with their patients regarding advanced care early during treatment, it results in patients receiving care that is in line with their goals and wishes. While guidelines recommend conversations with high-risk patients regarding advanced care, many patients with cancer die without ever having had this conversation. Because oncologists are only able to […]

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Olaparib Improves Outcomes in BRCA-Altered Castration-Resistant Prostate Cancer

Mutations in the DNA damage repair genes BRCA 1 and BRCA2 increase a tumor’s susceptibility to treatment with poly(ADP)ribose polymerase (PARP) inhibitors. This treatment approach is standard in breast and ovarian cancers, where these mutations commonly occur. Mutations in BRCA1/2 and the DNA damage repair gene ATM occur in as many as 30% of patients […]

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CDK4/6 Inhibitors Demonstrate Consistent Survival Benefit in Breast Cancer

For patients with metastatic hormone receptor (HR)-positive, HER2-negative breast cancer, treatment with a cyclin dependent kinase 4/6 (CDK 4/6) inhibitor in combination with endocrine therapy is a highly effective treatment option. Three CDK4/6 inhibitors are currently approved in the United States in this setting. At the ESMO Congress 2019, final results from the MONARCH 2 […]

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Postsurgical Radiotherapy Not Necessary for Prostate Cancer

For men with early-stage prostate cancer, the standard of care for many years has been radical prostatectomy followed by adjuvant radiotherapy to prevent disease recurrence. However, the benefits of radiotherapy in this setting are not well documented and can be associated with numerous toxic effects. At the ESMO Congress 2019, results from a large clinical […]

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Nivolumab/Ipilimumab Associated With High Rates of Long-Term Survival in Melanoma

In the past decade, the 5-year survival rate for patients with metastatic melanoma has increased dramatically, from less than 5% with chemotherapy to 20% with ipilimumab monotherapy. More recently, the introduction of PD-1 and PD-L1 inhibitors into the care of patients with metastatic melanoma has further improved survival outcomes, particularly when used in combination with […]

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Two Years of Hormone Therapy Increases Mortality in Recurrent Prostate Cancer

Treatment with antiandrogen therapy is a standard of care for men with prostate cancer receiving salvage radiotherapy following postsurgical biochemical recurrence. This standard, based in part on results from the randomized phase III RTOG 9601 trial, found that the addition of 2 years of antiandrogen therapy to postoperative radiotherapy resulted in a significant improvement in […]

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