Luspatercept Reduces Blood Transfusion Dependence in Lower-Risk MDS

Anemia is a major morbidity associated with low- and intermediate-risk myelodysplastic syndrome (MDS), and patients with MDS often become dependent on red blood cell (RBC) transfusion to counteract symptoms of anemia. Luspatercept, a first-in-class erythroid-maturation agent, is involved in regulation of late stage RBC maturation and is currently being investigated as a treatment for patients […]

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Ibrutinib Regimens Outperform Chemoimmunotherapy in Newly Diagnosed CLL

From December 1 to December 4, more than 25,000 attendees from around the world gathered in San Diego, California, to attend the 60th American Society for Hematology (ASH) Annual Meeting, where the latest developments and new findings in the hematology field were presented. Over the next several weeks, prIME Lines will highlight some of the […]

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First-Line Avelumab Plus Axitinib Outperforms Sunitinib in RCC

For many years, the standard front-line therapy for advanced renal cell carcinoma (RCC) with clear cell histology was single-agent treatment with a vascular endothelial growth factor (VEGF) targeting tyrosine kinase inhibitor (TKI). Recently, however; immunotherapy with the PD-1 inhibitor nivolumab in combination with the CTLA-4 inhibitor ipilimumab was approved for use in patients with intermediate- […]

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Atezolizumab Combo, a New First-Line Option for Advanced NSCLC

For newly diagnosed patients with advanced non-small cell lung cancer (NSCLC) without targetable driver mutations, the standard of care for many years was platinum-doublet chemotherapy. Recently, however; immunotherapy with PD-1 inhibitor pembrolizumab, either alone (for patients with PD-L1 expression over 50%) or in combination with platinum-based chemotherapy were approved as new standard for first-line treatment […]

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First-Line Pembrolizumab Superior to EXTREME in Metastatic SCCHN

For years, first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has been the combination of platinum chemotherapy, 5-fluorouracil (5-FU), and cetuximab followed by cetuximab maintenance, commonly known as the EXTREME regimen. This regimen is associated with an overall survival (OS) of about 10 months. It has substantial toxicity but is […]

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Local RT Improves Survival in Low Metastatic Burden Prostate Cancer

Men with newly diagnosed, metastatic prostate cancer are typically treated with systemic therapy, including androgen deprivation therapy (ADT), and receive local therapy for symptom palliation if needed. However, retrospective data suggest that local radiotherapy to the primary tumor may have an impact on survival in metastatic prostate cancer and patients with better prognoses may benefit […]

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First-Line Olaparib Maintenance New Standard for BRCAm Ovarian Cancer

Treatment for newly diagnosed advanced ovarian cancer most often includes cytoreductive surgery and platinum-based chemotherapy. While this combination is highly effective, most patients will relapse within three years. For recurrent platinum-sensitive ovarian cancer, maintenance with poly(ADP-ribose) polymerase (PARP) inhibitors such as olaparib, niraparib, and rucaparib is standard of care following platinum-based chemotherapy, based on substantial […]

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Survival Benefit of Palbociclib/Fulvestrant in HR+/HER2- Breast Cancer

In recent years and across multiple lines of therapy, the combination of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors with hormonal therapy has become a standard of care for patients with advanced, hormone-receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative breast cancer. As previously reported, in the PALOMA-3 trial (N = 521) the combination of the CDK4/6 […]

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Atezolizumab/Nab-Paclitaxel Combo New Standard of Care for PD-L1+ TNBC

The 2018 European Society for Medical Oncology (ESMO) Congress was held from October 19 to 23 in Munich, Germany. Nearly 28,000 participants, including oncology professionals, patient advocates, and industry representatives, attended from around the world to hear the most recent updates in oncology, focusing on innovation, integration, and sustainability of cancer care. Over the next […]

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CT Screening Reduces Lung Cancer Mortality in High-Risk Men and Women

The uptake of lung cancer screening is low, despite the fact that the National Lung Screening Trial (NLST) found a 20% relative reduction in lung cancer mortality for high-risk individuals (current and former heavy smokers) with annual screening using low-dose computed tomography (CT). Interestingly, a post-hoc analysis of this trial suggested a differential benefit of […]

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