Proton Beam Radiotherapy Safer Than Traditional Radiotherapy

Concurrent chemoradiotherapy (CCRT) is a standard treatment approach for many patients with early stage, non-metastatic cancers. While this approach is highly effective in reducing tumor size and can be curative in some patients, it is often associated with severe side effects that can impact patient quality-of-life. Proton beam radiotherapy (PBRT) is an alternative to traditional […]

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Risk Factors for Opioid Misuse Among Patients With Cancer

Opioid misuse is a major public health concern. Because many patients with cancer rely on pain medication to manage cancer symptoms, there is a risk for opioid dependence in this population. To clarify the risk of opioid dependence among patients with cancer, a recent study evaluated common factors associated with opioid misuse among 106,732 cancer […]

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PSA Screening for Prostate Cancer Among Men With BRCA2 Mutations

Mutations in BRCA1 and BRCA2 genes are highly associated with increased risk of breast and ovarian cancer among women. In men, presence of between BRCA2 mutations has been shown to be associated with an increased risk of prostate cancer and overall poor prognosis. Early detection is key in successful treatment of prostate cancer, and prostate […]

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Full Chemotherapy Dose Improves Survival in Early Breast Cancer

For patients with early-stage breast cancer, surgery followed by adjuvant chemotherapy is a standard of care. However, because of the toxicities associated with chemotherapy, many patients receive reduced or modified doses. A new study sought to evaluate the impact of full versus modified-dose adjuvant chemotherapy on breast cancer survival. The investigators analyzed data from 1,302 […]

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Impact of Exercise and Weight Loss on Breast Cancer Lymphedema Outcomes

Lymphedema is a common complication of curative breast cancer treatment, occurring in as many as 50% of patients undergoing axillary lymph node dissection. Because lymphedema occurs more commonly in patients with excess body weight, current guidelines recommend weight loss and home-based exercise as a strategy to manage breast cancer-related lymphedema. However, this recommendation has not […]

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New Guidelines on Management of Venous Thromboembolism

Cancer patients are significantly more likely to develop venous thromboembolism (VTE) than people without cancer. Appropriate risk assessment, prophylaxis, and management of VTEs is essential to prevent the long-term complications and risk of death from deep vein thrombosis and pulmonary embolism. In a new Clinical Practice Guideline released by the American Society for Clinical Oncology […]

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Antidepressants Linked to Reduced Cancer Mortality

Patients with cancer often experience depression and anxiety, and these comorbid conditions are independent risk factors for premature mortality. Many patients with cancer take antidepressants to manage these conditions, but little is known about the link between antidepressant use and mortality in patients with cancer. To evaluate this, a large, nationwide, 4-year historical cohort study […]

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Nivolumab Associated With Long-Term Survival in Multiple Tumors

Immunotherapy targeting the PD-1/PD-L1 axis has become a standard component of care across multiple tumor types, including non-small cell lung cancer (NSCLC), melanoma, renal cell carcinoma (RCC), and others. While these agents result in durable responses, there is limited data regarding long-term survival in these patients. In a secondary analysis of the phase I CA209-003 […]

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