Improving Healthcare Delivery in Immuno-Oncology via QI Initiatives

Cancer care is complex and rapidly evolving and providing high quality of cancer care for all patients with cancer is an important goal of healthcare providers worldwide. Treatment of cancer has been recently revolutionized with the introduction of immunotherapy, such as immune checkpoint inhibitors, that has demonstrated durable responses and improved survival in various cancers, […]

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Early Evidence of Activity of Trabectedin and Olaparib in Sarcoma

Bone and soft tissue sarcomas comprise a group of biologically diverse tumors that are associated with poor prognosis, despite an increasing number of treatment options that include chemotherapy and targeted therapy. Trabectedin is a safe and effective second-line therapy approved for treatment of advanced soft tissue sarcoma (STS). Poly(ADP ribose) polymerase (PARP) inhibitors are a […]

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Immune Checkpoint Inhibitors Effective in BRAF-Mutant NSCLC

Immune checkpoint inhibitors targeting PD-1 and PD-L1 have become standard first-line therapy for patients with advanced non-small cell lung cancer (NSCLC), but only for patients without activating mutations in EGFR or ALK, as tumors harboring these alterations do not respond well to immunotherapy. In recent years, BRAF-mutated NSCLC has emerged as a recognized molecular subtype […]

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Sequential Brentuxiamb Vedotin For Hodgkin Lymphoma in the Elderly

Outcomes of patients with advanced Hodgkin lymphoma over the age of 60 tend to be inferior compared to younger patients.  One major challenge in treating this patient population is their generally poor health and inability to tolerate toxic chemotherapy regimens. Single-agent therapy with antibody-drug conjugate brentuximab vedotin (BV) has been shown to be an effective […]

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New FDA Approved Indications for Oncology and Hematology in August

First Chemotherapy-Free Treatment for Waldenströms Macroglobulinemia. The combination of the Bruton tyrosine kinase inhibitor ibrutinib (Ibruvica®, Abbvie) and the anti-CD20 monoclonal antibody rituximab (Rituxan®, Genentech) was approved by the United States Food and Drug Administration (FDA) for treatment of patients with Waldenströms macroglobulinemia (WM). Approval of this regimen was based on results from the phase […]

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Baseline steroids

Baseline Steroids Diminish Benefits of PD-(L)1 Blockade in NSCLC

Immunotherapy with PD-1 and PD-L1 immune checkpoint inhibitors has become the standard of care in patients with non-small cell lung cancer (NSCLC) who do not express targetable alterations such as epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK), or ROS1 translocation/rearrangements. Because these agents function by stimulating the immune response, use of immunosuppressive […]

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Dual HER2 Blockade and AI for HER2+/HR+ Advanced Breast Cancer

Treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive and hormone receptor (HR)-positive advanced breast cancer is challenging because bidirectional cross talk between the estrogen receptor and HER2 can lead to the development of resistance to both hormonal and anti-HER2 therapy. In these patients, adding anti-HER2 to aromatase inhibitor (AI) therapy demonstrated improved […]

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PET May Predict Long-Term Benefit With Anti-PD-1 Therapy in Melanoma

PD-1 targeting immune checkpoint inhibitors have revolutionized treatment of metastatic melanoma, resulting in long-term survival in many patients. However, there are few reliable predictors of long-term response to anti-PD-1 therapy in these patients. Currently, complete response (CR) by computed tomography (CT) imaging is considered the best indicator for long-term outcomes, and it appears that these […]

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Nivolumab ± Ipilimumab Effective for Refractory Esophagogastric Cancer

There are few therapeutic options for patients with metastatic chemotherapy refractory esophagogastric cancer, and prognosis for these patients is poor. Immunotherapy with PD-1 targeting immune checkpoint inhibitors has been shown to be a highly effective treatment option across a variety of solid tumors. Preclinical and early clinical data support the role for immune checkpoint blockade […]

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Talazoparib Outperforms Chemotherapy in BRCA+ Advanced Breast Cancer

For patients with advanced breast cancer who carry a germline mutation in BRCA1 or BRCA2, and are thus deficient in the repair mechanism for DNA double-strand breaks, treatment with a poly(adenosine diphosphase) polymerase (PARP) inhibitor is a highly effective therapeutic option. Talazoparib is a novel, highly potent PARP inhibitor that demonstrated promising responses among pretreated […]

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